A ventricular pressure-clamping system for the study of mechano-electrical feedback / 生理学报
Acta Physiologica Sinica
;
(6): 606-610, 2006.
Article
in English
| WPRIM
| ID: wpr-265409
ABSTRACT
It is necessary to control the mechanical stimuli precisely in the studies of cardiac mechano-electrical feedback (MEF). In the present study a ventricular pressure-clamping system has been developed, which can be applied to isolated-perfused rabbit hearts. Controlled by a computer, this system not only can make the left ventricle follow a command defining the same pressure wave as that during a beating cycle under physiological condition, but also deliver mechanical stimuli with a proper waveform to the ventricle at a particular time phase. This system integrates multiple functions, including perfusing, pacing, recording of electrocardiogram and monophasic action potentials, and clamping and measuring of ventricular pressures in isolated-perfused hearts. Thus, it is a distinct system for investigating the phenomena and mechanisms of cardiac MEF at organ level.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
In Vitro Techniques
/
Action Potentials
/
Ventricular Pressure
/
Constriction
/
Electrocardiography
/
Feedback
/
Heart
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2006
Type:
Article
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