Effect of melatonin on glial fibrillary acidic protein, nuclear factor-kB and synaptophysin expressions in aging mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2043-2047, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-265722
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of melatonin on the expressions of glial fibrillary acidic protein (GFAP), nuclear factor-κB (NF-κB p65) and synaptophysin in mice of different ages.</p><p><b>METHODS</b>Twenty young male B6C3F1 mice (5.5 months) and 20 aged mice (26 months) were both divided into control and melatonin treatment (daily dose of 0.04 mg/kg) groups. After 2.5 months of treatment, the brain tissues of the mice were collected to examine the expressions of GFAP, NF-κB and SYN by immunohistochemistry.</p><p><b>RESULTS</b>In the control groups, the expression of NF-κB p65 in the brain tissue increased with age, whereas a reverse change was found in melatonin-treated aged rats (P<0.05). Synaptophysin expression also decreased with age, but melatonin treatment significantly enhanced its expression in aged mice (P<0.05). GFAP expression in the brain tissue increased with age regardless of melatonin treatment (P>0.05).</p><p><b>CONCLUSION</b>GFAP expression is almost not affected by melatonin treatment in aged mice. Melatonin can reduce the expression levels of NF-κB p65 and synaptophysin in the brain tissue to protect the brain and slow down the aging process.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Brain
/
Aging
/
Chimera
/
NF-kappa B
/
Synaptophysin
/
Transcription Factor RelA
/
Genetics
/
Glial Fibrillary Acidic Protein
/
Melatonin
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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