Assessment of the mechanical properties and biocompatibility of a new electrospun polyurethane vascular prosthesis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2006-2011, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-265730
ABSTRACT
<p><b>OBJECTIVE</b>To develop a small-caliber vascular grafts and study its morphologies, mechanical properties and biocompatibility.</p><p><b>METHODS</b>The effects of electrospinning conditions on the microstructure and porosity of the resulting scaffolds were investigated for preparation of a small-caliber (4 mm) polyurethane vascular grafts with optimum microstructures and mechanical properties. The mechanical properties and biocompatibility of the prepared grafts were evaluated.</p><p><b>RESULTS</b>The polyurethane vascular grafts showed a three-dimensional reticular structure consisting of nanofibers, with an average porosity of (51.48∓4.47)% and tensile strength of 5.85 ∓ 0.62 MPa. The grafts provided a better long-term support than e-PTFE graft for endothelial cell growth and endothelialization.</p><p><b>CONCLUSION</b>The polyurethane vascular prosthesis possessed favorable microstructures, excellent mechanical properties and good biocompatibility for potential clinical application.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyurethanes
/
Prosthesis Design
/
Tensile Strength
/
Biocompatible Materials
/
Materials Testing
/
Blood Vessel Prosthesis
/
Cell Adhesion
/
Chemistry
/
Porosity
/
Mechanical Phenomena
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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