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Clinical efficacy of rosuvastatin in lipid management in Chinese patients in Hong Kong / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2814-2819, 2009.
Article in English | WPRIM | ID: wpr-266034
ABSTRACT
<p><b>BACKGROUND</b>Rosuvastatin has been claimed to be more potent than other statins in its ability to lower the low-density lipoprotein (LDL) cholesterol levels. This study aimed to investigate the clinical efficacy of rosuvastatin in LDL cholesterol lowering therapy for new or switched hyperlipidaemic Chinese patients.</p><p><b>METHODS</b>This study was a retrospective one in patients who took rosuvastatin in the outpatient clinics of Prince of Wales Hospital during the period of July 1, 2004 to June 30, 2005. The prescribing pattern, the utilization pattern and the side effect profile were recorded. Attainment of lipid goals for each patient was assessed according to the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III guidelines.</p><p><b>RESULTS</b>A total of 261 Chinese patients (mean age (64.8 +/- 12) years; 55.6% male) were recruited into the study. The mean LDL-cholesterol level was (3.50 +/- 1.29) mmol/L prior to Rosuvastatin and (2.30 +/- 1.73) mmol/L after Rosuvastatin treatment (P < 0.0001). Rosuvastatin raised the LDL-cholesterol goal achievement rate from 28.0% to 74.3% in all patients combined (P < 0.0001) and from 11.0% to 79.0% for statin naive patients (P < 0.0001). Approximately 4% of patients developed side effects including myalgia, elevated liver enzymes, and dizziness.</p><p><b>CONCLUSION</b>Rosuvastatin was effective in improving LDL-cholesterol goal attainment and lowering LDL-cholesterol and triglyceride (TG) levels in either newly started or switched patients.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrimidines / Sulfonamides / Blood / Retrospective Studies / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Therapeutic Uses / Rosuvastatin Calcium / Fluorobenzenes / Cholesterol, LDL Type of study: Practice guideline / Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrimidines / Sulfonamides / Blood / Retrospective Studies / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Therapeutic Uses / Rosuvastatin Calcium / Fluorobenzenes / Cholesterol, LDL Type of study: Practice guideline / Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2009 Type: Article