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Karyotype analysis of qualified sperm donors on preliminary screening / 中华男科学杂志
National Journal of Andrology ; (12): 13-16, 2011.
Article in Chinese | WPRIM | ID: wpr-266220
ABSTRACT
<p><b>OBJECTIVE</b>To explore the significance of karyotype analysis in screening sperm donors.</p><p><b>METHODS</b>From January 1, 2004 to December 31, 2008, a total of 2537 potential sperm donors passed our preliminary screening, and all were routinely karyo-typed via peripheral blood. Follow-ups were conducted on the pregnancy outcome and congenital malformation after artificial insemination with the sperm from the qualified donors.</p><p><b>RESULTS</b>Among the 2537 qualified sperm donors, 2362 were of the normal karyotype 46, XY and 135 showed polymorphism. Abnormal karyotype was found in 6 cases, and controversial abnormal karyotype in 34.</p><p><b>CONCLUSION</b>Karyotype analysis can reduce the risk of chromosomal disease in neonates from artificial insemination, and genetic counseling for abnormal karyotype sperm donors may help them solve their future reproductive problems.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Sperm Banks / Genetic Testing / Chromosome Aberrations / Chromosome Disorders / Genetics / Gonadal Dysgenesis, 46,XY / Karyotyping Type of study: Diagnostic study / Prognostic study / Screening study Limits: Adult / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Sperm Banks / Genetic Testing / Chromosome Aberrations / Chromosome Disorders / Genetics / Gonadal Dysgenesis, 46,XY / Karyotyping Type of study: Diagnostic study / Prognostic study / Screening study Limits: Adult / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2011 Type: Article