Karyotype analysis of qualified sperm donors on preliminary screening / 中华男科学杂志
National Journal of Andrology
;
(12): 13-16, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-266220
ABSTRACT
<p><b>OBJECTIVE</b>To explore the significance of karyotype analysis in screening sperm donors.</p><p><b>METHODS</b>From January 1, 2004 to December 31, 2008, a total of 2537 potential sperm donors passed our preliminary screening, and all were routinely karyo-typed via peripheral blood. Follow-ups were conducted on the pregnancy outcome and congenital malformation after artificial insemination with the sperm from the qualified donors.</p><p><b>RESULTS</b>Among the 2537 qualified sperm donors, 2362 were of the normal karyotype 46, XY and 135 showed polymorphism. Abnormal karyotype was found in 6 cases, and controversial abnormal karyotype in 34.</p><p><b>CONCLUSION</b>Karyotype analysis can reduce the risk of chromosomal disease in neonates from artificial insemination, and genetic counseling for abnormal karyotype sperm donors may help them solve their future reproductive problems.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tissue Donors
/
Sperm Banks
/
Genetic Testing
/
Chromosome Aberrations
/
Chromosome Disorders
/
Genetics
/
Gonadal Dysgenesis, 46,XY
/
Karyotyping
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2011
Type:
Article
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