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Determination of GATA-4 in the testis of the mouse / 中华男科学杂志
National Journal of Andrology ; (12): 901-904, 2010.
Article in Chinese | WPRIM | ID: wpr-266248
ABSTRACT
<p><b>OBJECTIVE</b>To explore the characteristics and distribution of GATA-4 in the testis of male mice.</p><p><b>METHODS</b>Paraffin sections were obtained from the testes of 24 male B6SJLF1/J mice, aged 0 day (n = 6), 2 weeks (n = 6), 4 weeks (n = 6) and 6 weeks (n = 6), and the expressions of GATA-4 in the testis were observed by the immunohistochemical ABC method and DAB visualization at different times.</p><p><b>RESULTS</b>Positive expressions of GATA4 were found in the Sertoli cells and Leydig cells of all the mice, but significantly higher in the 4- and 6-week-old than in the 0-day and 2-week-old groups (P < 0.01). And they were also observed in the germ cells of the 4- and 6-week-old mice, significantly higher in the latter than in the former (P < 0.01).</p><p><b>CONCLUSION</b>GATA-4 exists in the testis of male mice, which has provided a morphological base for sex determination and differentiation and hormone regulation in the testis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sertoli Cells / Testis / Cell Differentiation / Cell Biology / GATA4 Transcription Factor / Germ Cells / Leydig Cells / Metabolism Limits: Animals Language: Chinese Journal: National Journal of Andrology Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sertoli Cells / Testis / Cell Differentiation / Cell Biology / GATA4 Transcription Factor / Germ Cells / Leydig Cells / Metabolism Limits: Animals Language: Chinese Journal: National Journal of Andrology Year: 2010 Type: Article