Efficacy of postoperative chemoradiation for stage III low rectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 748-750, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-266278
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of postoperative chemoradiation for stage III low rectal cancer.</p><p><b>METHODS</b>A total of 132 patients with stage III low rectal cancer, including 69 males and 63 females, were identified and divided into two groups group A received chemoradiation while group B underwent chemotherapy alone.</p><p><b>RESULTS</b>Eighteen patients developed local recurrence after five years of follow-up, with 6 cases(8.3%) in group A and 12(22.2%) in group B(P<0.05). In patients with distant metastasis(n=65), 37(47.4%) were in group A and 28(51.9%) in group B, and the difference was not statistically significant(P>0.05). The 5-year survival rates for group A and group B were 47.4% and 29.6%, respectively(P<0.05). Radiation proctitis was found in 6 cases in group A.</p><p><b>CONCLUSIONS</b>Postoperative chemoradiation can reduce local recurrence rate and improve 5-year survival compared to chemotherapy alone. However, it has little effect on the distant metastasis. Postoperative chemoradiation is safe and effective for low rectal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Radiotherapy
/
Rectal Neoplasms
/
Therapeutics
/
Antineoplastic Combined Chemotherapy Protocols
/
Treatment Outcome
/
Combined Modality Therapy
/
Drug Therapy
/
Neoplasm Recurrence, Local
/
Neoplasm Staging
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2010
Type:
Article
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