Stereoselectivity in absorption of trans tramadol in rat intestine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 893-896, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-266559
ABSTRACT
<p><b>AIM</b>To investigate the stereoselectivity in absorption of trans tramadol (trans T) in rat intestine.</p><p><b>METHODS</b>The duodenum, jejunum and ileum were separately perfusated in situ with trans T dissolved in Krebs-Ringer buffer. Trans T enantiomers in the perfusate were analyzed with a high performance capillary electrophoresis (HPCE) method.</p><p><b>RESULTS</b>The absorbed fractions of trans T enantiomers were similar among the different segments of the rat intestine. The absorbed fraction of (+)-trans T was lower than that of (-)-trans T when the concentration of trans T was not higher than 40 mumol.L-1. As the concentration of trans T increased, the absorbed fractions of trans T enantiomers were reduced and the difference in absorbed fractions between trans T enantiomers became not significant.</p><p><b>CONCLUSION</b>Trans T enantiomers can be absorbed in different parts of the rat intestine. The intestinal absorption of trans T was stereoselective, (-)-trans T being preferentially absorbed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stereoisomerism
/
Tramadol
/
Pharmacokinetics
/
Rats, Sprague-Dawley
/
Duodenum
/
Analgesics, Opioid
/
Ileum
/
Intestinal Absorption
/
Intestine, Small
/
Jejunum
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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