Secondary structure of insulin encapsulated within liposomes / 药学学报
Acta Pharmaceutica Sinica
;
(12): 863-866, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-266566
ABSTRACT
<p><b>AIM</b>To determine the secondary structure of insulin encapsulated within liposomes.</p><p><b>METHODS</b>The secondary structure of insulin, mixture of insulin with liposomes (I) and insulin liposomes (II) were determined by Fourier transform infrared (FTIR) spectroscopy.</p><p><b>RESULTS</b>The figures of secondary structure of insulin, sample I and II were similar. The results showed that the amount of alpha-helix and beta-sheet of insulin, sample I and II had little difference, from 36.09% (insulin) to 31.68% (sample I) and 31.45% (sample II), and from 47.83% (insulin) to 53.29% (I) and 51.36% (II), respectively. The results showed that the insulin of sample I and II did not insert in liposomes membrane, only adsorbed or extendedon the surface of the liposomes.</p><p><b>CONCLUSION</b>The secondary structure of insulin encapsulated within liposomes has not been destroyed and still remain the original state.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug Carriers
/
Chemistry
/
Drug Delivery Systems
/
Protein Structure, Secondary
/
Spectroscopy, Fourier Transform Infrared
/
Insulin
/
Liposomes
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS