Studies on formulations of Panax notoginsenosides for intranasal administration / 药学学报
Acta Pharmaceutica Sinica
;
(12): 859-862, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-266567
ABSTRACT
<p><b>AIM</b>To develop high bioavailability preparations without irritation for Panax notoginsenosides.</p><p><b>METHODS</b>The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined.</p><p><b>RESULTS</b>Saponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation.</p><p><b>CONCLUSION</b>Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Bufo bufo
/
Administration, Intranasal
/
Drug Carriers
/
Pharmacokinetics
/
Biological Availability
/
Cellulose
/
Chemistry
/
Drug Delivery Systems
/
Cyclodextrins
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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