Stability studies of sulfated polyguluronic acid ester / 药学学报
Acta Pharmaceutica Sinica
;
(12): 711-714, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-266583
ABSTRACT
<p><b>AIM</b>To test the stability of marine polysaccharide drug sulfated polyguluronic acid ester.</p><p><b>METHODS</b>Four methods including high performance gel chromatography (HPGC), poly-acrylamide gel electrophoresis (PAGE), UV scan of absorbance between 200 and 800 nm and gelatin nephelometry were established. Samples were tested in high temperature, high humidity, strong light and accelerated test conditions. The methods were used to test the changes of the parameters including molecular weight, molecular weight distribution, absorbance between 200 and 800 nm, free sulfate, with which we could estimate the stability of sulfated polyguluronic acid ester could be estimated.</p><p><b>RESULTS</b>The four methods were suitable to test the stability of sulfated polyguluronic acid ester and the sample were stable in the conditions as before except in high temperature.</p><p><b>CONCLUSION</b>Sulfated polyguluronic acid ester has good stability.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polysaccharides, Bacterial
/
Spectrophotometry, Ultraviolet
/
Temperature
/
Chemistry
/
Chromatography, Gel
/
Drug Stability
/
Electrophoresis, Polyacrylamide Gel
/
Methods
/
Molecular Weight
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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