Effects of 50 Hz sinusoidal electromagnetic field with different intensities on rat peak bone mass / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 116-136, 2015.
Article
in Zh
| WPRIM
| ID: wpr-266716
Responsible library:
WPRO
ABSTRACT
Studying effects of 50 Hz sinusoidal electromagnetic fields (SEMFs) with different intensities on peak bone mass (PBM) of rats may provide a theoretical basis for application of electromagnetic clinical field. 30 female SD rats, 6 weeks of age, were randomly divided into three groups: the control group, 0.1 mT electromagnetic field group (EMFs) and 0.6 mT EMFs. The EMFs groups were treated for 3 h/day. After 8 weeks, we examined their bone mineral densities (BMD) , measured their bone biomechanical properties, and made serum levels of osteocalcin (OC), tartrate-resistant acid phosphatase 5b (TRACP 5b), and histomorphometry. It was found that the BMD (P < 0.01), maximum mechanical load (P < 0.01) in the 0.1 mT group were significantly higher than those in the control group, and Yield strength (P < 0.05), the analyses of serum bone turnover markers and histomorphometric parameters were better than those in the control group (P < 0.05). However, the 0.6 mT group did not have significantly difference comparing with that in the control group. This study proved that 50 Hz 0.1 mT SEMFs can increased BMD, bone strength, and bone tissue microstructure. Therefore, 50 Hz 0.1 mT SEMFs can improve peak bone mass of rats.
Full text:
1
Index:
WPRIM
Main subject:
Physiology
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Acid Phosphatase
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Blood
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Bone and Bones
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Bone Density
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Osteocalcin
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Rats, Sprague-Dawley
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Electromagnetic Fields
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Tartrate-Resistant Acid Phosphatase
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Isoenzymes
Limits:
Animals
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2015
Type:
Article