Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 135-138, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-266801
ABSTRACT
<p><b>OBJECTIVE</b>To find new active constituents from Rhizome of Cimicifuga foetida.</p><p><b>METHOD</b>Various column chromatographic techniques were employed for isolation and purification. The structures were elucidated on the basis of spectral and chemical evidences.</p><p><b>RESULT</b>Four triterpenoid compounds were isolated and identified as 7,8-didehydro-27-deoxyactein(1), 24-O-acetylshengmanol-3-O-beta-D-xyl (23R, 24R)[2], cimigenol(3), cimigenol-3-O-beta-D-xyl(4).</p><p><b>CONCLUSION</b>Compound 1 is a new compound, 2-4 were obtained from this medicinal material for the first time. The antiosteoporosis activity screening in vitro(by the method of SRB) indicates that Compounds 1, 2 and 4 can promote the proliferation for rat Osteoblastoma cell line (UMR106) at the concentration of 10(-9) kg.L-1.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Triterpenes
/
Bone Neoplasms
/
Molecular Structure
/
Cell Division
/
Chemistry
/
Osteoblastoma
/
Rhizome
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2003
Type:
Article
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