Effects of puerarin on fatty superoxide in aged mice induced by D-galactose / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of puerarin on fatty superoxide of aged mice induced by D-galactose.</p><p><b>METHOD</b>The aged mice were induced by s.c. 0.12 g.kg-1 D-galactose for 6 weeks. Meanwhile, they were treated with three doses of puerarin once a day for 6 weeks. Then the spontaneous behavior was tested in the aged mice using open field at the next day after the last treatment. And the activity of SOD, the contents of MDA and lipofuscin in brain, liver, and serum were measured with Ultravioletray spectrometer and Fluorospectrophometer analysis system.</p><p><b>RESULT</b>Compared with the D-galactose control group, puerarin of 50 mg.kg-1 and 100 mg.kg-1 puerarin significantly increased the spontaneous behavior, remarkably promoted the activity of SOD of brain, liver, and serum in the aged mice, and significantly decreased the contents of MDA and lipofuscin.</p><p><b>CONCLUSION</b>Puerarin can improve the activity of antioxidase of the modelling aged-mice induced by D-galactose.</p>