Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection / 감염과화학요법
Infection and Chemotherapy
; : 330-333, 2016.
Article
in En
| WPRIM
| ID: wpr-26684
Responsible library:
WPRO
ABSTRACT
There have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (HPS), most of which were treated successfully using adequate antibiotics. Here, we report a case of Epstein-Barr virus (EBV)-associated HPS after scrub typhus infection that was not improved using antirickettsial treatment. A 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-day doxycycline therapy. Physical and laboratory data showed hepatosplenomegaly, bicytopenia, hyperferritinemia, and hypofibrinogenemia. A bone marrow examination (BM) revealed hypercellular marrow with hemophagocytosis and histiocyte infiltration. EBV was detected in BM aspirates using polymerase chain reaction. After a diagnosis of HPS was made, the patient was treated successfully using high-dose steroids.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Steroids
/
Bone Marrow
/
Bone Marrow Examination
/
Scrub Typhus
/
Polymerase Chain Reaction
/
Doxycycline
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Herpesvirus 4, Human
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Epstein-Barr Virus Infections
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Diagnosis
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Lymphohistiocytosis, Hemophagocytic
Type of study:
Diagnostic_studies
Limits:
Aged
/
Humans
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Male
Language:
En
Journal:
Infection and Chemotherapy
Year:
2016
Type:
Article