Anti-emetic effect of ethanol extract from "Wuzhuyu broth" / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 862-866, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-266844
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-emetic effect of ethanol extract from "WuZhuYu broth" and its mechanism.</p><p><b>METHOD</b>Three experiments were carried out test which extract has anti-emetic activity, such as CuSO4-induced pigeon's emetic response, gastric emptying in mice and ACh-induced or 5-HT-induced contraction in vitro gastric muscle in rats. Meanwhile, effect of anti-emetic extract on concentration-response curve to ACh, 5-HT, histamine was investigated.</p><p><b>RESULT</b>50% ethanol extract and 70% ethanol extract were identified as having significantly stronger anti-emetic activities with little side effect, which showed the significant effect on concentration-response curve to ACh, 5-HT, histamine.</p><p><b>CONCLUSION</b>50% ethanol extract and 70% ethanol extract contain more anti-emetic fractions, more anti-emetic fractions can be gained at the concentrations of 50% and 70% ethanol; the mechanism of anti-emetic effect is related to its antagonism to the receptors of ACh, 5-HT, histamine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Columbidae
/
Plants, Medicinal
/
Vomiting
/
Drugs, Chinese Herbal
/
Chemistry
/
Rats, Sprague-Dawley
/
Evodia
/
Therapeutic Uses
/
Drug Combinations
/
Drug Therapy
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2002
Type:
Article
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