Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of purariae isoflavone on estrogen level in ovariectomized rats.</p><p><b>METHOD</b>80 rats were divided into four groups randomly, every group with 20 rats 1. Control group; 2. Normal + purariae isoflavone group; 3. Ovariectomized group; 4. Ovariectomized + purariae isoflavone group. Estrogen level and gonadotropin-releasing hormone level of all rats were measured.</p><p><b>RESULT</b>Thirty days after being ovariectomized, E2, E3 level was significantly lower than that of the first group(P < 0.05). But Testerone, FSH, LH, PRL and GH increased(P < 0.05). After being gastrogavaged with purariae-isolfavone for thirty days, Estrogen level and gonadotropin-relasing hormone level of the second group were significantly lower in various degree than those of normal control group (P < 0.05). But in ovariectomized rats, the estrogen level was recovered (P > 0.05). The gonadotropin-releasing hormone level was increased (P < 0.05).</p><p><b>CONCLUSION</b>Purariae-isoflavone can increase estrogen level to normal in ovariectomized rats by way of increasing the level of gonadotropin-releasing hormone. In normal rats, it has anti-estrogen effect.</p>