Sensitivity of the Cytomegalovirus Antigenemia Assay to Diagnose Cytomegalovirus Retinitis
Infection and Chemotherapy
;
: 302-308, 2016.
Article
in English
| WPRIM
| ID: wpr-26688
ABSTRACT
BACKGROUND:
Cytomegalovirus (CMV) retinitis is one of the most important tissue-invasive CMV diseases in immunocompromised patients. Since 1980, non-invasive diagnostic methods, notably the CMV antigenemia assay, have been widely used as adjunct tests to diagnose tissue-invasive CMV diseases. However, there are limited data on the diagnostic value of the CMV antigenemia assay for diagnosing CMV retinitis. MATERIALS ANDMETHODS:
We performed a retrospective review of all cases of CMV retinitis at Asan Medical Center, Seoul, South Korea over a 9-year period. The diagnosis of CMV retinitis was made by experienced ophthalmologists according to medical history and an ophthalmoscopic appearance of typical retinopathy, together with absence of an alternative diagnosis.RESULTS:
We analyzed 44 patients with CMV retinitis (affecting 57 eyes) for whom the CMV antigenemia assay was performed. Of the 44 patients, 31 (70%) were HIV-uninfected and 13 (30%) were HIV-infected. The overall sensitivity of the CMV antigenemia assay was 66% (95% confidence interval [CI] 50–80%). The test’s sensitivity showed a non-significant trend towards being higher in HIV-infected patients than in HIV-uninfected patients (sensitivity 85% vs 58%, respectively, P = 0.16). In a subgroup analysis of the 35 patients without other concurrent tissue-invasive CMV disease, the sensitivity of the CMV antigenemia assay was 57% (95% CI 40–74%).CONCLUSIONS:
The CMV antigenemia assay has limited value as a non-invasive diagnostic adjunct test for CMV retinitis. Therefore, the results of the assay need to be interpreted in the context of underlying disease, clinical presentation, and ophthalmoscopic findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retinitis
/
Retrospective Studies
/
Immunocompromised Host
/
Cytomegalovirus Retinitis
/
Cytomegalovirus
/
Diagnosis
/
Seoul
/
Korea
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Infection and Chemotherapy
Year:
2016
Type:
Article
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