Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 885-891, 2017.
Article
in English
| WPRIM
| ID: wpr-266889
ABSTRACT
<p><b>BACKGROUND</b>Patients on hemodialysis have a high-mortality risk. This study analyzed factors associated with death in patients on maintenance hemodialysis (MHD). While some studies used baseline data of MHD patients, this study used the most recent data obtained from patients just prior to either a primary endpoint or the end of the study period to find the characteristics of patients preceding death.</p><p><b>METHODS</b>Participants were selected from 16 blood purification centers in China from January 2012 to December 2014. Patients' data were collected retrospectively. Based on survival status, the participants were divided into two groups survival group and the death group. Logistic regression analysis was performed to determine factors associated with all-cause mortality.</p><p><b>RESULTS</b>In total, 4104 patients (57.58% male, median age 59 years) were included. Compared with the survival group, the death group had more men and more patients with diabetic nephropathy (DN) and hypertensive nephropathy. The patients preceding death also had lower levels of diastolic blood pressure, hemoglobin, serum albumin, serum calcium, serum phosphate, Kt/V, and higher age. Multivariate analysis revealed that male sex (odd ratio [OR] 1.437, 95% confidence interval [CI] 1.094-1.886), age (OR 1.046, 95% CI 1.036-1.057), and presence of DN (OR 1.837, 95% CI 1.322-2.552) were the risk factors associated with mortality. High serum calcium (OR 0.585, 95% CI 0.346-0.989), hemoglobin (OR 0.974, 95% CI 0.967-0.981), albumin (OR 0.939, 95% CI 0.915-0.963) levels, and dialysis with noncuffed catheter (OR 0.165, 95% CI 0.070-0.386) were protective factors based on a multivariate analysis.</p><p><b>CONCLUSIONS</b>Hemodialysis patients preceding death had lower hemoglobin, albumin, and serum calcium levels. Multivariate analysis showed that male sex, age, DN, low hemoglobin, low albumin, and low serum calcium were associated with death in hemodialysis patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
China
/
Multivariate Analysis
/
Retrospective Studies
/
Risk Factors
/
Mortality
/
Renal Dialysis
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Chinese Medical Journal
Year:
2017
Type:
Article
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