Identification of hydrolysates and alcoholysates of aconitum alkaloids / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To identify products decomposed in high temperature water and alcohol from diester alkaloids such as aconitum alkaloid, in order to study their transformation regularity.</p><p><b>METHOD</b>Structures of multiple converted products were determined by analyzing on multistage mass spectrometry of known compounds and literature searching.</p><p><b>RESULT</b>Benzaconine and pyraconitine were the major hydrolysates, while pyraconitine and ethoxy-aconitine were the major alcoholysates from diester alkaloids.</p><p><b>CONCLUSION</b>Pyraconitine alkaloids, as pyrolytic products, are not related to the type of solvent. 8-ethoxy-aconitine alkaloids, as alcoholysates, are related to the type of solvent. This study identifies multiple converted products from alkaloids and summarizes mass spectrometry fragmentation regularity by LC-MS, laying a firm foundation for studies on the transformation of toxic diester alkaloids contained in aconitum and providing a basis for studies on the transformation of alkaloids contained in aconitum during boiling.</p>