Your browser doesn't support javascript.
loading
Alpha-glucosidase inhibitory active constituents contained in nutshell of Trapa acornis / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1408-1411, 2012.
Article in Chinese | WPRIM | ID: wpr-267007
ABSTRACT
<p><b>OBJECTIVE</b>To study chemical constituents in nutshell of Trapa acornis and in vitro inhibitory activity against alpha-glucosidase.</p><p><b>METHOD</b>EtOAC and n-butanol extractive fractions were separated by chromatography and their structures were identified by multiple spectroscopic techniques.</p><p><b>RESULT</b>Nine compounds were separated, they were 4,23,24-trimethylcholest-22-en-3-ol (1), stigmasterol (2), alpha-amyrin (3), (+)-nyasol (4), oleanolic acid (5), ursolic acid (6), hederagenin (7), 3,23-dihydroxy-12-ursen-28-oic acid (8) and beta-daucosterol (9). Total extracts from T. acornis nutshells, petroleum ether fractions, acetic ether fractions and normal butanol fractions showed inhibitory activity against alpha-glucosidase. Compound 5 (IC50 2.88 mg x L(-1)) and 6 (IC50 4.42 mg L(-1)) showed stronger inhibitory activity against alpha-glucosidase.</p><p><b>CONCLUSION</b>All compounds except compound 2 were separated from the genus for the first time, and compound 1-9 were separated from this plant for the first time.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemistry / Lythraceae / Enzyme Inhibitors / Glycoside Hydrolase Inhibitors Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2012 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemistry / Lythraceae / Enzyme Inhibitors / Glycoside Hydrolase Inhibitors Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2012 Type: Article