Association of IL-7 with disease progression in Chinese HIV-1 seropositive individuals / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 288-293, 2006.
Article
in English
| WPRIM
| ID: wpr-267137
ABSTRACT
<p><b>BACKGROUND</b>Elevated levels of interleukin-7 (IL-7) have been correlated with CD4(+) T cell depletion and the emergence of syncytium-inducing (SI) variants in human immunodeficiency virus type-1 (HIV-1) infection, and suggested as an indicator of acquired immunodeficiency syndrome (AIDS) disease progression. Therefore, we investigated the effects of IL-7 on disease progression and virus phenotype in Chinese HIV/AIDS patients.</p><p><b>METHODS</b>In a cross-sectional study of 71 untreated HIV-1 seropositive individuals and 12 healthy donors, plasma IL-7 levels were determined by an ultra sensitive enzyme-linked immunosorbent assay (ELISA), and its relations to CD4(+) T cells, CD8(+) T cells, plasma viral loads and HIV phenotypes were analyzed.</p><p><b>RESULTS</b>Significant higher IL-7 levels were found in Chinese HIV/AIDS patients [(3.33 +/- 3.60) pg/ml] than those of health controls [(1.2 +/- 0.81) pg/ml] (P < 0.05), and IL-7 levels were inversely associated with CD4(+) T cell counts (r = -0.497, P < 0.01). Furthermore, IL-7 levels were significant higher in patients with SI variants [(9.12 +/- 4.55) pg/ml] than those with non-syncytium-inducing variants [(1.50 +/- 2.69) pg/ml] (P < 0.01).</p><p><b>CONCLUSIONS</b>Increased IL-7 levels were found in Chinese HIV/AIDS patients and significantly associated with disease progression, thus increased IL-7 plasma levels may indicate disease progression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Physiology
/
Virology
/
Blood
/
HIV-1
/
HIV Seropositivity
/
Interleukin-7
/
Disease Progression
/
CD4 Lymphocyte Count
/
Viral Load
Type of study:
Observational study
Limits:
Adult
/
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2006
Type:
Article
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