Therapeutic effects of electroacupuncture at ST36 acupoint on sodium-taurocholate-induced severe acute pancreatitis / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 695-700, 2014.
Article
in English
| WPRIM
| ID: wpr-267231
ABSTRACT
<p><b>OBJECTIVE</b>To explore the protective effects and mechanisms of electroacupuncture (EA) at Zusanli (ST36) acupoint in rats with severe acute pancreatitis (SAP).</p><p><b>METHODS</b>Sixty-six male Sprague-Dawley rats were randomly assigned to three groups of 22 each a SAP model group (SAP group), a shamoperated group (sham group) and a EA at ST36 acupoint group (EA group). A rat model of SAP was induced by pancreatic duct injection with 3.5% sodium taurocholate. EA was performed at ST36 acupoint for 30 min after induction of SAP and 30 min before sacrificed. The rats were killed at 3 h (n=7), 6 h (n=7) and 12 h (n=8) after operation, and blood samples were taken for the measurement of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and acetylcholine (Ach) by enzyme-linked immunosorbnent assay. The pathological changes of pancreatic tissue, volume of ascites and pancreatic weight/body weight ratio were measured.</p><p><b>RESULTS</b>The serum concentrations of TNF-α and IL-6 in the EA group were significantly lower than in the SAP group at 3, 6 and 12 h after the operation (p<0.05). Serum Ach in the EA group was significantly higher than in the SAP group at various time points after operation (p<0.05). The other parameters were clearly improved after treatment with EA.</p><p><b>CONCLUSION</b>EA at ST36 acupoint might have a therapeutic effect in rats with SAP through activating the cholinergic anti-inflammatory pathway.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatitis
/
Taurocholic Acid
/
Therapeutics
/
Severity of Illness Index
/
Enzyme-Linked Immunosorbent Assay
/
Acetylcholine
/
Electroacupuncture
/
Acute Disease
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2014
Type:
Article
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