Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-beta1 in the bleomycin -induced pulmonary fibrosis / 中国针灸
Chinese Acupuncture & Moxibustion
;
(12): 790-792, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-267327
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of moxibustion arresting the pulmonary fibrosis and provide experimental basis for prevention and treatment of pulmonary fibrosis with acupuncture and moxibustion.</p><p><b>METHODS</b>One hundred and forty SD rats were randomly assigned to 4 groups a blank group, a model group, a moxibustion group and a prednisone group, 35 rats in each group. The 3 groups expect the blank group were injected with bleomycin via trachea to induce experimental pulmonary fibrosis model, and 7 days after modeling, they were treated with moxibustion at bilateral Feishu (BL 13) and Gaohuang (BL 43), 3 cones each point, once each day, 10 days constituting one therapeutic course with an interval of one day between courses. After 3 courses, all rats were killed and expressions of TGF-beta1mRNA were detected with PCR method.</p><p><b>RESULTS</b>The content of TGF-beta1mRNA in the pulmonary tissue in the moxibustion group and the prednisone group was significantly lower than the model group (P < 0.01), and there was no significant difference between the moxibustion group and the prednisone group (P > 0. 05).</p><p><b>CONCLUSION</b>Both moxibustion at Feishu (BL 13) and Gaohuang (BL 43), and prednisone treatment can significantly suppress the expression of TGF-beta1mRNA in the pulmonary tissue in the rat of bleomycin-induced pulmonary fibrosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Fibrosis
/
Bleomycin
/
Rats, Sprague-Dawley
/
Transforming Growth Factor beta1
/
Genetics
/
Moxibustion
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Acupuncture & Moxibustion
Year:
2005
Type:
Article
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