Clinical analysis of 34 patients with adrenal metastasis from breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 855-857, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-267441
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical characteristics and prognosis of adrenal metastasis from breast cancer, and to explore methods to improve prognosis.</p><p><b>METHODS</b>Thirty-four breast cancer patients with adrenal metastasis were diagnosed and treated in our hospital from Jan. 1999 to Dec. 2010. SPSS 17.0 was used for survival analysis.</p><p><b>RESULTS</b>During the Jan. 1999 to Dec. 2010 period, 13 595 patients with breast cancer were treated in our hospital. Among them, 34 cases had adrenal metastasis from breast cancer, with an incidence of 0.25%. The median time to progression (TTP) and overall survival of the 34 patients was 6.2 months (95%CI 3.1-9.3 months) and 21.4 months (95%CI 0-44.0 months), respectively. Eleven patients (34.4%) achieved partial response among 32 patients who received chemotherapy, and 10 (31.2%) achieved stable disease. Patients who achieved best response of PR or SD were superior in TTP and OS than patients with disease progression after chemotherapy (TTP 18.1 months vs. 2.3 months, P < 0.001; OS 35.2 months vs. 10.3 months, P = 0.003). Patients who received 1st or 2nd line chemotherapy were superior in TTP than patients who received over 2nd line chemotherapy (TTP 15.7 months vs. 4.2 months, P = 0.005).</p><p><b>CONCLUSIONS</b>The incidence of adrenal metastasis from breast cancer is low. Chemotherapy-based systemic therapy should be recommended to improve the prognosis for these patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
General Surgery
/
Remission Induction
/
Breast Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Survival Rate
/
Retrospective Studies
/
Adrenal Gland Neoplasms
/
Carcinoma, Ductal, Breast
/
Adrenalectomy
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2013
Type:
Article
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