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Effect of arctiin on mouse podocyte epithelial-mesenchymal transition induced by advanced oxidation protein products / 南方医科大学学报
Journal of Southern Medical University ; (12): 379-382, 2012.
Article in Chinese | WPRIM | ID: wpr-267595
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of arctiin on mouse podocyte epithelial-mesenchymal transition (EMT) induced by advanced oxidation protein products (AOPP).</p><p><b>METHODS</b>Mouse podocytes were stimulated by 200 µg/ml AOPP for 24 h in the presence of 50, 100, 200, and 400 µmol/L arctiin. The expressions of α-smooth muscle actin, Grp78 and CHOP were detected using Western blotting.</p><p><b>RESULT</b>The expressions of α-SMA, Grp78 and CHOP were inhibited by arctiin, showing a dose-dependent effect within a given range of arctiin concentration.</p><p><b>CONCLUSION</b>AOPP causes endoplasmic reticulum stress to induce EMT of mouse podocytes, and arctiin can decrease EMT by alleviating the stress. This finding sheds light on a new scope of research of renal fibrosis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Cell Line / Actins / Podocytes / Transcription Factor CHOP / Epithelial-Mesenchymal Transition / Endoplasmic Reticulum Stress / Advanced Oxidation Protein Products / Furans Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Cell Line / Actins / Podocytes / Transcription Factor CHOP / Epithelial-Mesenchymal Transition / Endoplasmic Reticulum Stress / Advanced Oxidation Protein Products / Furans Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2012 Type: Article