Ozone therapy combined with sulfasalazine delivered via a colon therapy system for treatment of ulcerative colitis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2683-2685, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-267708
ABSTRACT
<p><b>OBJECTIVE</b>To assess the therapeutic effect of ozone therapy combined with sulfasalazine sulfasalazine delivered via a colon therapy system in the treatment of distal ulcerative colitis.</p><p><b>METHODS</b>This prospective randomized controlled clinical trial involved 54 patients with mild to moderate active distal ulcerative colitis, who were randomize into 3 groups in accordance with the inclusion criteria (n=18). Each group was given sulfasalazine at the daily dose of 2 g, and in colon therapy group and ozone therapy plus sulfasalazine therapy group, sulfasalazine was delivered via a colon therapy system on a daily basis; the control group received sulfasalazine via retention enema only. At 0, 2, and 4 weeks of the treatment, colonoscopy was performed to evaluate the disease activity, and biopsy samples were obtained at 0 and 4 weeks for histological examination.</p><p><b>RESULTS</b>In comparison with colon therapy group and control group, ozone therapy plus colon therapy resulted in more rapid alleviation of the clinical symptoms and better histological improvement without any adverse effects.</p><p><b>CONCLUSION</b>Ozone therapy combined with sulfasalazine delivered via a colon therapy system is feasible and effective for treatment of ulcerative colitis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ozone
/
Sulfasalazine
/
Therapeutics
/
Colitis, Ulcerative
/
Prospective Studies
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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