Segregation of sex chromosomes in the spermatozoa of 46, XY/47, XXY patients with oligozoospermia by dual fluorescence in-situ hybridization / 中华男科学杂志
National Journal of Andrology
; (12): 841-843, 2004.
Article
in Zh
| WPRIM
| ID: wpr-267800
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the segregation of sex chromosomes in the spermatozoa of a 46, XY/47, XXY patient with oligozoospermia.</p><p><b>METHODS</b>The number of X and Y chromosomes of the ejaculated spermatozoa from the patient with mosaic 46, XY/47, XXY was analysed by X/Y dual fluorescence in-situ hybridization (FISH).</p><p><b>RESULTS</b>Of the 100 spermatozoa analysed, 97 showed either one X chromosome-specific green signal or one Y-chromosome-specific red Y signal in each spermatozoon and only 3 showed no signal. The frequencies of X- and Y-bearing spermatozoa were 49% and 48% respectively. The ratio of X- to Y-bearing spermatozoa was about 1:1 as expected. There was no statistical difference between the chromosome XX and XY frequencies in each spermatozoon from the patient in comparison with those estimated in the control.</p><p><b>CONCLUSION</b>The spermatozoa of 46, XX/47, XXY mosaic patients have a normal gonosomal complement, which allows infertility treatment to be carried out by ICSI.</p>
Full text:
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Index:
WPRIM
Main subject:
Oligospermia
/
Therapeutics
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In Situ Hybridization, Fluorescence
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Sperm Injections, Intracytoplasmic
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Chromosomes, Human, X
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Chromosomes, Human, Y
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Genetics
/
Klinefelter Syndrome
Limits:
Adult
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Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2004
Type:
Article