Application of NOD/SCID mice in research of experimental hematology - review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 964-968, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-267848
ABSTRACT
NOD/SCID (non-obese diabetic/severe combined immunodeficient) mice are immune deficient mice which are made by backcross of severe combined immunodeficient mice with non-obese diabetic mice strains. NOD/SCID mice are both innate immune deficiencies and lack of T and B lymphocytes. Various tumor cells can be implanted in this kind of mice, the rejection and graft-versus-host disease (GVHD) occur fewer. Therefore, NOD/SCID mice gradually become a useful tool for the study on Experimental Hematology. This paper comprehensively reviews the biological characteristics of NOD/SCID mice, the establishment of human leukemia model, stem cell transplantation, drug research, deficiency and improvement of NOD/SCID mice in application for study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Research
/
Leukemia
/
Mice, SCID
/
Mice, Inbred NOD
/
Models, Animal
/
Disease Models, Animal
/
Hematology
/
Methods
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2008
Type:
Article
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