Gene expression profile of human TGF-beta signal transduction pathway of B cell type acute lymphocytic leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 742-745, 2008.
Article
in Zh
| WPRIM
| ID: wpr-267898
Responsible library:
WPRO
ABSTRACT
This study was aimed to investigate the gene expression profile of TGF-beta signal transduction pathway in B-cell type acute lymphocytic leukemia (B-ALL). The gene expression profiles in B-ALL primary cells and cell lines (NALM6 cells, Raji cells), B-lymphocyte of control were detected by cDNA microarray including 113 different genes in human TGF-beta/BMP signal transduction pathway, and TGF-beta(1) mRNA expression was detected by real time RT-PCR. The B lymphocytes in peripheral blood of heacthy persons sorted by flow cytometry were used as control. The difference between them was compared. The results showed that as compared with B lymphocytes in peripheral blood of heacthy persons, the TGF-beta(1) expression in B-ALL cells, NALM6 cells and Raji cells were down-regulationed, myc and smad1 gene expressions were up-regulated, IL-6, smad 7 gene expressions were down-regulated. It is concluded that TGF-beta signal transduction is abnormal in B-cell type acute lymphocytic leukemia.
Full text:
1
Index:
WPRIM
Main subject:
RNA, Messenger
/
Leukemia, B-Cell
/
Signal Transduction
/
Acute Disease
/
Transforming Growth Factor beta
/
Gene Expression Profiling
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2008
Type:
Article