Comparison of transdermal permeation in vitro of lidocaine tincture and microemulsion / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To compare lidocaine tincture and microemulsion for their transdermal permeation.</p><p><b>METHODS</b>The experimental model for percutaneous administration of lidocaine preparations in vitro was prepared using modified Franz diffusion cell.</p><p><b>RESULTS</b>The accumulated infiltration amount of lidocaine microemulsion in unit area was higher than that in its cream or tincture preparations.</p><p><b>CONCLUSION</b>The transdermal permeation of lidocaine microemulsion in vitro can be more efficient than that of the tincture preparation, and the permeation is linearly dependent on the dose administered within a certain range.</p>