Expression of hypoxia-inducible factor-1alpha in endometriosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 538-540, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268082
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis.</p><p><b>METHODS</b>Immunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically.</p><p><b>RESULTS</b>The expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium.</p><p><b>CONCLUSION</b>HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Endometriosis
/
Endometrium
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Genetics
/
Menstrual Cycle
/
Metabolism
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS