Distribution and drug resistance spectrum analysis of 2478 clinical bacterial and Candida isolates / 南方医科大学学报
Journal of Southern Medical University
;
(12): 524-527, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268086
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution and drug resistance spectrum of clinical bacterial and Candida isolates.</p><p><b>METHODS</b>Most of the bacterial isolates were identified using automated BD Phoenix, and a few with K-B method carried out manually. Candida isolates were identified by color-display plate and K-B method.</p><p><b>RESULTS</b>The most common isolates in the 2478 strains were P. aeruginosa (15.6%), E. coli (11.5%), C. albicans (9.6%), K. pneumoniae (9.3%), S. aureu (8.2%), and S. epidermidis (7.5%). In gram-negative isolates, the antibiotics with the lowest resistance rate were meraopenem (14.4%), cefoperazone/Sulbactam (14.8%), Imipenem (21.9%), piperacillin/tazobactam (27.4%), ceftazidime (30.0%), amikacin (31.1%), and cefepime (33.1%). The detection rate of E.coli and K. pneumoniae isolates producing extended spectrum beta-lactamase (ESBLs) were 47.4% and 37.3% respectively. In gram-positive isolates, the antibiotics with the lowest resistance rate were vancomycin (0.9%), teicoplanin (1.1%), nitrofurantoin (6.9%), amikacin (20.1%), chloramphenicol (30.7%), and cefoperazone/sulbactam (31.5%). The methecillin-resistant rates of S. aureu , S. epidermidis, and S. haemolyticus were 57.1%, 65.0%, and 66.0%. For Candida isolates, the most sensitive antibiotics were amphotericin B (0.3%), nystain (0.3%), itraconazole (5.6%), fluconazole (9.4%), and fluorocytosine (9.4%).</p><p><b>CONCLUSION</b>The results suggest high rate of ESBL production and oxacillin resistance of the bacteria isolated in the hospital. More rational use of antimicrobial agents is crucial for reducing the drug-resistance of the bacteria, and effective measures must be taken to reduce dissemination of multidrug-resistant bacteria.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxacillin
/
Pharmacology
/
Bacteria
/
Beta-Lactamases
/
Candida
/
Microbial Sensitivity Tests
/
Drug Resistance, Bacterial
/
Drug Resistance, Fungal
/
Anti-Infective Agents
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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