Value of perioperative adjuvant therapy in liver transplantation for advanced hepatocellular carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 471-473, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268102
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical value of perioperative adjuvant chemotherapy in prevention of tumor recurrence and improvement of patient survival after liver transplantation for advanced hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Twenty patients with advanced HCC (pTNM stages III and IV a) receiving liver transplantation with preoperative transcatheter arterial chemoembolization (TACE) and postoperative adjuvant chemotherapy (ADM+5-Fu+CDDP) were retrospectively reviewed in comparison with 16 patients receiving liver transplantation only for tumor recurrence, cumulative and tumor-free survivals. The feasibility and side-effects of the treatments were also studied.</p><p><b>RESULTS</b>The recurrence rate was lower in the perioperative treatment group than in non-treatment group (12/20, 60.0% vs 11/16, 87.5%, P<0.05). The 1- and 2-year overall survival rates were 70.8% and 47.1% for the chemotherapy group and 43.8% and 20.5% for the non-chemotherapy group respectively, showing significant differences between them (P<0.05). The 1- and 2-year tumor-free survival rates were 60.6%, 40.5% and 33.6%, 15.6% in the two groups, respectively, with also significant differences (P<0.05).</p><p><b>CONCLUSIONS</b>Perioperative adjuvant treatment may significantly decrease the likeliness of tumor recurrence and prolong the survival of patients with advanced HCC after liver transplantation. Chemotherapy with ADM+5-Fu+CDDP can be effective and safe with only mild side-effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Survival Rate
/
Retrospective Studies
/
Liver Transplantation
/
Treatment Outcome
/
Chemotherapy, Adjuvant
/
Carcinoma, Hepatocellular
/
Perioperative Care
/
Drug Therapy
/
Liver Neoplasms
/
Neoplasm Recurrence, Local
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS