Clinical study of double filtration plasmapheresis for treatment of refractory myasthenia gravis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 355-357, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268136
ABSTRACT
<p><b>OBJECTIVE</b>To assess the therapeutic effect, timing of administration, complication prevention and management of the double filtration plasmapheresis (DFP) in the treatment of refractory myasthenia gravis (MG).</p><p><b>METHODS</b>Thirty-one patients with refractory MG were treated with KM 8800 membrane plasmapheresis monitor. DFP was performed every 3 days and the exchanging liquid was composed of 50 ml of 20% albumen and 1000 ml plasma substitute. Physical examination for absolute clinical score and blood sample was collected for AchR-Ab determination early in the morning on days 0, 3, 7, 14 of DFP.</p><p><b>RESULTS</b>With a total effective rate of 91.9%, complete recovery, basic recovery, improvement, and response was achieved in 2, 4, 11, and 17 patients, respectively, whereas the other 3 failed to respond. Hypotension occurred twice in 2 cases and was corrected after symptomatic treatment.</p><p><b>CONCLUSION</b>DFP may effectively lower blood AchR-Ab level of with minimal complications, and can be valuable for treatment of refractory MG.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma Exchange
/
Autoantibodies
/
Therapeutics
/
Blood
/
Retrospective Studies
/
Receptors, Cholinergic
/
Treatment Outcome
/
Allergy and Immunology
/
Filtration
/
Methods
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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