Synthesis and biological activity of a series of benzopyran derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 162-168, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-268152
ABSTRACT
Thirteen benzopyran derivatives were synthesized and their activity stimulating the differentiation of preadipocytes into adipocytes were evaluated with 3T3-L1 cells. Compound 8 was also tested for its hypoglycemic activity on db diabetes mice model. Results indicated that compounds 3, 8 and 11 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, and compound 8 can reduce the blood-sugar level of db diabetes mice dramatically.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Benzopyrans
/
Blood
/
Blood Glucose
/
Cell Differentiation
/
Chemistry
/
Adipocytes
/
3T3-L1 Cells
/
Diabetes Mellitus, Experimental
/
Hypoglycemic Agents
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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