Effect of resveratrol on chronic obstructive pulmonary disease in rats and its mechanism / 药学学报
Acta Pharmaceutica Sinica
;
(12): 128-132, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-268158
ABSTRACT
The purpose of this study is to establish COPD animal model by intra-tracheal instillation of bleomycin (BLM) once and exposure to cigarette smoke for continuous 27 d, and to observe the effects of the inhalation on the model. At the 29th day, blood samples were taken from cervical artery for blood-gas analysis and parameters of lung function were recorded. Bronchoalveolar lavage fluid (BALF) was collected to measure intercellular adhesion molecule-1 (ICAM-1) concentration. The results showed that atomization inhaled resveratrol could alleviate rat COPD lung injury accompanied by amelioration of pathological changes, increase the ratio of forced expiratory volume in 0.3 s (FEV0.3) and forced vital capacity (FVC), and decrease the ICAM-1 level in BALF. The ultimate reduction of inflammatory factors was involved, at least in part, in the mechanism of resveratrol effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Stilbenes
/
Bleomycin
/
Blood Gas Analysis
/
Bronchoalveolar Lavage Fluid
/
Smoking
/
Random Allocation
/
Chemistry
/
Forced Expiratory Volume
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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