Advances in the study of molecular mechanisms, applications and screening for altered peptide ligand / 药学学报
Acta Pharmaceutica Sinica
;
(12): 113-117, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-268161
ABSTRACT
Altered peptide ligand (APL), a short peptide with immune regulatory activity and substitutions of a single or multiple amino acids in an antigenic peptide, has shown potential therapeutic effect on autoimmune disease, tumor and virus infection. APL regulates immune responses by interfering the interaction between the major histocompatibility complex (MHC), antigenic peptide and T cell receptor (TCR), or by regulating the intracellular signaling of antigen presenting cells, bystander suppression and inducing heterogenous immune responses. High-specific and high-affinity APL screened from peptide laboratory by phage display, has a potential to be a new resource for drug with antigen specificity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Autoimmune Diseases
/
Therapeutics
/
Receptors, Antigen, T-Cell
/
Peptide Library
/
Therapeutic Uses
/
Allergy and Immunology
/
Immunotherapy
/
Ligands
/
Major Histocompatibility Complex
Type of study:
Diagnostic study
/
Screening study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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