Recent advances in the study of pin1 and its inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 9-17, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-268180
ABSTRACT
Pin1 is a phosphorylation-dependent peptidyl-prolyl cis/trans isomerase, which specifically catalyzes the amide bond isomerization of phosphoserine-proline or phosphothreonine-proline in mitotic phosphoproteins. Pin1 induces the conformational changes to control the function of phosphoproteins. Depletion of Pinl on various human cancer cell lines cause mitotic arrest and apoptosis. Pin1 is an attracting therapeutic target for anticancer and its inhibitors might be potential anticancer drug. In this review, Pin1 inhibitors and the catalytic mechanism, the biological function of Pin1 and its role in oncogenesis are summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phosphoproteins
/
Phosphorylation
/
Signal Transduction
/
Chemistry
/
Apoptosis
/
Peptidylprolyl Isomerase
/
Enzyme Inhibitors
/
NIMA-Interacting Peptidylprolyl Isomerase
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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