Structure modification on sesquiterpene lactones from Elephantopus scaber / 药学学报
Acta Pharmaceutica Sinica
; (12): 1159-1161, 2007.
Article
in Zh
| WPRIM
| ID: wpr-268212
Responsible library:
WPRO
ABSTRACT
In order to look for lower toxic and strongly active compounds, the structure of sesquiterpene lactones from Elephantopus scaber was modified. Deoxyelephantopin and scabertopin were isolated from the whole plant of Elephantopus scaber and hydrogenated and epoxidated. Five sesquiterpenoide derivatives were prepared and their structures were identified by IR, NMR and MS spectra analysis. Four sesquiterpenoides are new compounds. Part of the compounds show definite antitumor activity.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Plants, Medicinal
/
Sesquiterpenes
/
Terpenes
/
HeLa Cells
/
Molecular Structure
/
Chemistry
/
Asteraceae
/
Hydrogenation
/
Lactones
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article