Recent advances in the study of antifungal lead compounds with new chemical scaffolds / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1129-1136, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268218
ABSTRACT
In recent years, the incidence of infections caused by invasive fungal pathogens has increased dramatically. However, most antifungal agents used in clinic have many drawbacks and cannot meet the demand of the clinical use. Therefore, for the development of new generation of antifungal agents, it is of great significance to find antifungal lead compounds with novel chemical scaffolds and new mode of action. Novel antifungal lead compounds reported in recent years are reviewed. Their chemical structures, antifungal activity and structure-activity relationship are discussed in detail, and current problems and trends in future research are also emphasized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pyridines
/
Structure-Activity Relationship
/
Berberine
/
4-Butyrolactone
/
Molecular Structure
/
Chemistry
/
Cholestanols
/
Naphthoquinones
/
Cycloleucine
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article
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