Potential role of microRNAs in human diseases and the exploration on design of small molecule agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1115-1121, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268220
ABSTRACT
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene modulation by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. miRNA alterations are involved in the initiation and progression of human diseases. miRNA-expression profiling of human diseases has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. Recent evidence has suggested miRNAs as viable therapeutic targets for a wide range of human diseases. Several approaches were performed, the experimental examination of these techniques and the resultant findings not only indicate feasibility of interfering miRNA action in a gene-specific fashion but also may provide a new research tool for studying function of miRNAs. The new approaches also have the potential of becoming alternative gene therapy strategies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
RNA, Messenger
/
Drug Design
/
Genetic Therapy
/
Gene Expression Regulation
/
Gene Expression Profiling
/
Gene Silencing
/
MicroRNAs
/
Genetics
/
Heart Diseases
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article
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