Alteration of interleukin-17/interferon-γ double positive cells in mice with Coxsackie virus induced myocarditis / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 1135-1139, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-268244
ABSTRACT
<p><b>OBJECTIVE</b>To observe the alteration of interleukin-17 and interferon-γ double positive cells (IL-17(+)/IFN-γ(+) cells) in mice with coxsackie virus B3 (CVB3) induced acute viral myocarditis (VMC).</p><p><b>METHODS</b>VMC was induced in male Balb/c mice by peritoneal injection of CVB3. Control mice received PBS injection. At 0, 1, 2, 3, 4 and 6 weeks after injection, pathological scores were determined on hematoxylin-eosin stained heart sections and flow cytometric analysis was performed to evaluate the percent of IL-17(+)/IFN-γ(+) cells among CD4(+) T cells.</p><p><b>RESULTS</b>Compared to control mice, the pathological scores of VMC mice were higher on CVB3 infection week 1 (1.8 ± 0.5), peaked on week 2 (2.8 ± 0.5) and declined thereafter. However, the proportion of IL-17(+)/IFN-γ(+) cells remained steadily at a low level throughout the observation period and was similar between VMC and control mice.</p><p><b>CONCLUSIONS</b>Our data shows that IL-17(+)/IFN-γ(+) cells might not be involved in the inflammation process of CVB3 induced VMC mice model.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Virology
/
Interferon-gamma
/
Enterovirus
/
Interleukin-17
/
Coxsackievirus Infections
/
Disease Models, Animal
/
Allergy and Immunology
/
Th17 Cells
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2011
Type:
Article
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