Posttraumatic expression of MHC II molecules: an experimental and clinical study / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 50-52, 2000.
Article
in English
| WPRIM
| ID: wpr-268483
ABSTRACT
OBJECTIVE:
To evaluate the role of MHC II expression in posttrauma immune disturbances and infections.METHODS:
In experimental study, peritoneal macrophages were harvested from traumatized mice and treated with GM-CSF, Ia molecules were determined by flow cytometry. In 24 trauma patients, monocyte HLA-DR expression was measured by APAAP technique.RESULTS:
Marked inhibition of MHC II molecule expression was found in both traumatized mice and patients. In traumatic patients with infection, the inhibition was more severe. Treatment with GM-CSF in mice partially restored the Ia expression.CONCLUSIONS:
Inhibition of MHC II molecules plays an important role in postrauma immune disturbances. There is a close relationship between HLA-DR inhibition and clinical infections.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2000
Type:
Article
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