Cardiac contraction and calcium transport function after severe burn injury in rats / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 97-101, 2000.
Article
in English
| WPRIM
| ID: wpr-268532
ABSTRACT
OBJECTIVE:
To examine the function change of myocardial calcium transports and determined what role the change plays in cardiac dysfunction after severe burn injury in rats.METHODS:
The contraction and relaxation properties of the left ventricle (LV) were studied in the isolated hearts preparations of Wistar rats at 3, 8, and 24 h after a 30% TBSA (total body surface area) full-thickness burn. The calcium transport function of the sarcoplasmic reticulum (SR) was measured by the millipore filtration technique.RESULTS:
The maximal rate of LV pressure (plus minusdp/dtmax) of the burn group was significantly lower than that of the control group (P<0.01). In addition, the calcium-dependent ATPase activity and the coupling ratio of SR were also markedly depressed.CONCLUSIONS:
It indicates that the decrease in the SR calcium transport function is one of the important mechanisms for the cardiac contractile dysfunction after severe burn injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2000
Type:
Article
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