Recent progress in the study of HIV-1 transcription factor NF-kappaB and its inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1007-1012, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268538
ABSTRACT
Human immunodeficiency virus type 1 (HIV-1) transcription is a crucial step in the viral replication cycle, which is considered to be a potential target for inhibition of HIV-1 replication. Among the factors involved in this step, the cellular protein nuclear factor NF-kappaB is the most powerful inducer of HIV-1 transcription. HIV-1 transcription is initiated by the binding of NF-kappaB to the enhancer region in the long terminal repeat (LTR) of HIV-1. Several compounds suppress HIV-1 transcription through the inhibition of NF-kappaB activation. The mechanisms of NF-kappaB in the transcription of HIV-1 and progress of the current inhibitors of NF-kappaB are reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Transcription, Genetic
/
Virus Replication
/
HIV Long Terminal Repeat
/
NF-kappa B
/
HIV-1
/
Anti-HIV Agents
/
I-kappa B Proteins
/
I-kappa B Kinase
/
NF-KappaB Inhibitor alpha
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article
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