Stability of penicillin potassium with linear degradation programmed humidifying experiments / 药学学报
Acta Pharmaceutica Sinica
;
(12): 898-904, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268557
ABSTRACT
A linear degradation humidifying model for drug stability experiment is introduced. This new humidifying model is presented as H(r) = -M1-ln {exp(- MH(r,0)) - [exp(-MH(r,0)) -exp(-MH(r-m)) t(m)-t}. Where H(r) is the relative humidity; t is the time; H(r,m) and t(m) are the final relative humidity and time of the experiment, respectively. M is humidifying constant used in the humidifying program. In the new programmed humidifying model, a linear relationship between the content function of drugs and the relative humidity is obtained, the degradation of drugs can be more uniform within different humidity ranges and the experimental results are more accurate than those in the reported linear humidifying model. The stability of penicillin potassium, as a solid state model, was investigated by the linear degradation programmed humidifying and the exponential heating experiments. The results indicated that the kinetic parameters obtained by the linear degradation programmed humidifying and the exponential heating models were significantly more precise than those obtained by the linear programmed humidifying and the reciprocal heating models.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillins
/
Temperature
/
Kinetics
/
Chemistry
/
Technology, Pharmaceutical
/
Drug Stability
/
Humidity
/
Mathematics
/
Methods
/
Models, Chemical
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article
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