Difference absorption of l-tetrahydropalmatine and dl-tetrahydropalmatine in intestine of rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 534-537, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-268602
ABSTRACT
To investigate the difference in absorptive of tetrahydropalmatine (THP) and l-tetrahydropalmatine (l-THP) in rat intestine as well as the mechanism of the absorption of THP, in situ single pass perfusion model was used and the concentration of THP in perfusate was determined by HPLC. The absorption rate constant (k(a)) and effective permeability values (P(eff)) of THP had no significant difference (P > 0.05) at concentration of 8, 16 and 32 microg x mL(-1) in perfusion or in four different regions of intestine of rat (duodenum, jejunum, ileum, colon). The absorption of l-THP and THP in jejunum had significant difference (P < 0.05). The k(a) and P(eff) of THP increased obviously when verapamil was co-perfused with THP, while those of l-THP were not influenced by verapamil. The absorption of THP in intestine showed the passive diffusion process, and without a special absorption region. The stereoselective absorption difference may result from stereoselective combination of P-glycoprotein with d-THP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Permeability
/
Pharmacology
/
Stereoisomerism
/
Berberine Alkaloids
/
Pharmacokinetics
/
Verapamil
/
Chemistry
/
Sex Factors
/
Rats, Sprague-Dawley
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article
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