Expression of estrogen sulfotransferase in the mammary gland of hypertrophic breast and its significance / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 48-50, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-268646
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of estrogen sulfotransferase (EST) in the mammary gland of hypertrophic breast and its significance.</p><p><b>METHODS</b>EST expression in the mammary gland was detected by EnVision two step method of immunohistochemistry in 15 cases with normal breasts and 32 cases with hypertrophic breasts, including 19 gland-associated cases and 13 fat-associated cases.</p><p><b>RESULTS</b>The positive expression rate of EST in mammary gland was 34.4% (11/32) in hypertrophic group and 93.3% (14/15) in normal group, showing a significant difference between the two groups (P < 0.01). The positive expression rate of EST was 10.5% (2/19) in gland-associated group and 69.2% (9/ 13) in fat-associated group, showing a significant difference between the two groups (P < 0.01).</p><p><b>CONCLUSIONS</b>Decrease or deletion of EST in the mammary gland may be related to the development of hypertrophic breast, especially gland-associated hypertrophic breast.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Congenital Abnormalities
/
Breast
/
Sulfotransferases
/
Case-Control Studies
/
Mammary Glands, Human
/
Hypertrophy
/
Metabolism
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2011
Type:
Article
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