Expression of annexin V in decidua tissues of preeclampsia patients / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1438-1441, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-268737
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of annexin V in the decidua tissues of preeclampsia patients and explore its clinical significance.</p><p><b>METHODS</b>Real-time PCR, Western blotting and immunohistochemistry were employed to detect the mRNA and protein expressions of annexin V in the deciduas from 35 normal pregnant women at full term, 38 early onset severe preeclampsia patients and 33 late onset severe preeclampsia patients.</p><p><b>RESULTS</b>Annexin V was found on the cell membrane and in the cytoplasm of the decidual cells and stroma. Both the mRNA and protein of annexin V expressions in the decidua tissues were significantly different between normal pregnancy group and early or late onset severe preeclampsia group (P<0.05), being the highest in normal pregnancy group and the lowest in early onset severe preeclampsia group.</p><p><b>CONCLUSION</b>The low expression of annexin V in the deciduas might participate in the hypercoagulability state in preeclampsia patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pre-Eclampsia
/
RNA, Messenger
/
Immunohistochemistry
/
Case-Control Studies
/
Annexin A5
/
Decidua
/
Genetics
/
Metabolism
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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